Fibre-Rich Diet Protects Your Colon: Indian-Origin Scientists
New
York: A high fibre diet is essential for colon health and reduces the
risk of severe colon problems, shows research, alerting people not to
misuse antibiotics.
“A
high-fibre diet reduces the risk of colon problems and that when
fibre is lacking, vitamin B3 just may help keep the colon healthy as
well,” said Vadivel Ganapathy, from Medical College of Georgia at
Georgia Regents University (GRU) in the U.S.
The
researchers found that mice lacking the receptor - Gpr109a - were
prone to inflammation and cancer of the colon.
Doctors
gave mega-doses of vitamin B3 to mice whose healthy colonic bacteria
had been wiped out by antibiotics - a frequent occurrence in chronic
antibiotic use.
It
helped steer immune cells in the colon into a safe, anti-inflammatory
mode, according to the study published in the journal Immunity.
“Good
bacteria in the colon thrive on fibre and its digestion produces
butyrate, a short-chain fatty acid, which naturally activates the
receptor,” said Nagendra Singh, immunologist at the GRU Cancer
Centre.
“To
protect your colon, you need this receptor, as well as the fibre and
butyrate which activate it,” Ganapathy added.
For
people who cannot eat high-fibre diets, mega-doses of Vitamin B3
(niacin) may help protect the colon, the scientists suggest.
The
colon and intestines are constantly exposed to foreign bacteria that
enter the body primarily through the mouth.
The
good bacteria, which are essential to digestion and colon health,
regularly communicate to immune cells that they are not the enemy and
butyrate appears to be a key signal there as well, said the study.
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